颜光美，男，1957年4月生，博士，曾任中山大学副校长，广州国际企业孵化器总经理，华南新药创制中心主任。现任中山大学药理学教授, 博士生导师，国家杰出青年基金项目获得者 (1996年)，享国务院特殊津贴，人事部“百千万人才工程”第一、二层次人才，广州市创业领军团队带头人，广州市开发区创业领军人才，药理国家级精品课程带头人，教育部规划教材《药理学》主编，国家药监局主办期刊《中国药物警戒》专家，《知识分子》专家委员会成员。主要研究方向为“重大疾病的治疗学与机制研究：神经保护、实体瘤的诱导分化与溶瘤病毒”。获得国家发明专利40余项，获得卫生部、卫生厅三等奖1项、中国医科院科技三等奖1项、国家教委科技进步二等奖1项、广东省高教局卫生厅科技二等奖1项。在这些基金的资助下，颜教授在肿瘤和神经领域的主流学术（SCI收录）杂志发表论文100余篇，其中通讯/共同通讯作者论文80余篇，第一作者论文10余篇，包括Nature 子刊Nature Biotechnology, Nature Communications（5篇）, STTT，Science子刊Science Transcriptional Medicine, Cell子刊Cell Reports, PNAS（3篇）, Oncogene, Molecular Therapy（2篇）, Journal of Neuroscience等。参编外文脑肿瘤学领域专著2部。任高等教育出版社《药理学》（全国高等学校教材）主编。

代表性论文(*为通讯作者)：
(1)    Guangmei Yan*, Guojie Zhang, Xiaodong Fang, Yanfeng Zhang, Cai Li, Fei Ling, David N Cooper, Qiye Li, Yan Li, Alain J van Gool, Hongli Du, Jiesi Chen, Ronghua Chen, Pei Zhang, Zhiyong Huang, John R Thompson, Yuhuan Meng, Yinqi Bai, Jufang Wang, Min Zhuo, Tao Wang, Ying Huang, Liqiong Wei, Jianwen Li, Zhiwen Wang, Haofu Hu, Pengcheng Yang, Liang Le, Peter D Stenson, Bo Li, Xiaoming Liu, Edward V Ball, Na An, Quanfei Huang, Yong Zhang, Wei Fan, Xiuqing Zhang, Yingrui Li, Wen Wang, Michael G Katze, Bing Su, Rasmus Nielsen, Huanming Yang, Jun Wang, Xiaoning Wang & Jian Wang. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Nature Biotechnology, 2011, 29: 1019-1025. 
(2)    Haipeng Zhang#, Kai Li#, Yuan Lin#, Fan Xing, Xiao Xiao,Jing Cai, Wenbo Zhu,
Jiankai Liang, Yaqian Tan, Liwu Fu, Fang Wang, Wei Yin, Bingzheng Lu,Pengxin Qiu, Xingwen Su, Shoufang Gong, Xuetao Bai, Jun Hu*, Guangmei Yan*. Targeting VCP enhances anticancer activity of oncolytic virus M1 in hepatocellular carcinoma. Science translational medicine, 2017, 9(404): pii: eaam7996.
(3)    Wei Yin, Zong-ji Wang, Qi-ye Li, Jin-ming Lian, Yang Zhou, Bing-zheng Lu, Li-jun Jin, Peng-xin Qiu, Pei Zhang, Wen-bo Zhu, Bo Wen, Yi-jun Huang, Zhi-long Lin, Bi-tao Qiu, Xing-wen Su, Huan-ming Yang, Guo-jie Zhang, Guang-mei Yan* & Qi Zhou*. Evolutionary trajectories of snake genes and genomes revealed by comparative analyses of five-pacer viper. Nature Communications, 2016, 7:13107. 
(4)    Xiao Xiao#, Jiankai Liang#, Chunlong Huang, Kai Li, Fan Xing, Wenbo Zhu, Ziqing Lin, Wencang Xu,Guangen Wu, Jifu Zhang, Xi Lin, Yaqian Tan, Jing Cai, Jun Hu, Xueqin Chen, Youwei Huang, Zixi Qin,Pengxin Qiu, Xingwen Su, Lijun Chen, Yuan Lin*, Haipeng Zhang* & Guangmei Yan*. DNA-PK inhibition synergizes with oncolytic virus M1 by inhibiting antiviral response and potentiating DNA damage. Nature conmmunications. 2018, 9:4342.
(5)    Jiankai Liang#, Li Guo#, Kai Li, Xiao Xiao, Wenbo Zhu, Xiaoke Zheng, Jun Hu, Haipeng Zhang, Jing Cai, Yaya Yu, Yaqian Tan, Chuntao Li, Xincheng Liu, Cheng Hu, Ying Liu, Pengxin Qiu, Xingwen Su, Songmin He, Yuan Lin*, Guangmei Yan*. Inhibition of the mevalonate pathway enhances cancer cell oncolysis mediated by M1 virus. Nature conmmunications. 2018, 9(1):1524.
(6)    Yuan Lin#, Haipeng Zhang#, Jiankai Liang#, Kai Li, Wenbo Zhu, Liwu Fu, Fang Wang, Xiaoke Zheng, Huijuan Shi, Sihan Wu, Xiao Xiao, Lijun Chen, Lipeng Tang, Min Yan, Xiaoxiao Yang, Yaqian Tan, Pengxin Qiu, Yijun Huang, Wei Yin, Xinwen Su, Haiyan Hu, Jun Hu*, and Guangmei Yan*. Identification and characterization of alphavirus M1 as a selective oncolytic virus targeting ZAP-defective human cancers. Proc Natl Acad Sci USA, 2014,111(42):4504-4512.
(7)    Jing Cai#, Yuan Lin#, Haipeng Zhang, Jiankai Liang, Yaqian Tan, Webster Cavenee*, Guangmei Yan*. Selective replication of oncolytic virus M1 results in a bystander killing effect that is potentiated by Smac mimetics. Proc Natl Acad Sci USA, 2017, 114 (26): 6812-6817. 
(8)    Fan Xing, Yizhao Luan, Jing Cai, Sihan Wu, Jialuo Mai, Jiayu Gu, Haipeng Zhang, Kai Li, Yuan Lin, Xiao Xiao, Jiankai Liang, Yuan Li, Wenli Chen, Yaqian Tan,Longxiang Sheng, Bingzheng Lu, Wanjun Lu, Mingshi Gao，Pengxin Qiu, Xingwen Su,Wei Yin, Jun Hu, Zhongping Chen, Ke Sai , Jing Wang, Furong Chen, Yinsheng Chen, Shida Zhu， Dongbing Liu, Shiyuan Cheng, Zhi Xie*, Wenbo Zhu*, Guangmei Yan*. Anti-Warburg Effect Elicited by cAMP-PGC1α Pathway Drives Differentiation of Glioblastoma Cells into Astrocytes. Cell Reports, 2016, 18: 468-481. 
(9)    Kai Li#, Haipeng Zhang#, Jianguang Qiu, Yuan Lin, Jiankai Liang, Xiao Xiao,Liwu Fu, Fang Wang, Jing Cai, Yaqian Tan, Wenbo Zhu, Wei Yin, Bingzheng Lu, Fan Xing, Lipeng Tang, Min Yan, Jialuo Mai, Yuan Li, Wenli Chen, Pengxin Qiu, Xingwen Su, Guangping Gao, Phillip W L Tai, Jun Hu* and Guangmei Yan*. Activation of cyclic adenosine monophosphate pathway increases the sensitivity of cancer cells to the oncolytic virus M1. Molecular Therapy, 2016, 24(1): 156–165.
(10)    Sihan Wu, Yuan Lin, Dong Xu, Jiesi Chen, Minfeng Shu, Yuehan Zhou, Wenbo Zhu, Xingwen Su, Yuxi Zhou, Pengxin Qiu and Guangmei Yan*. MiR-135a Functions as a Selective Killer of Malignant Glioma. Oncogene, 2012, 31: 3866-3874. 
(11)    Yan Li, Wei Yin, Xia Wang, Wenbo Zhu, Yijun Huang and Guangmei Yan*: Cholera toxin induces malignant glioma cell differentiation via the PKA/CREB pathway. Proc Natl Acad Sci USA,  2007, 104: 13438-43. 
(12)    Haiyan Hu,  Yuehan Zhou,  Tiandong Leng,  Ailing Liu, Youqiong Wang, Xiuhua You,  Jingkao Chen, Lipeng Tang, Wenli Chen, Pengxin Qiu, Wei Yin, Yijun Huang, Jingxia Zhang, Liwei Wang, Hanfei Sang* and Guangmei Yan*. A major cholesterol  metabol i te cholestane-3β, 5α, 6β-triolfunctions as an endogenous neuroprotectant. Journal of Neuroscience, August 20, 2014, 34(34): 11426 –11438.