刘迎芳，男，1990年毕业于兰州大学生物系，获得理学学士学位。1990年至1993年在河北农业大学林学院任助教。1993年至1999年在北京大学生命科学学院就学，获理学博士学位。1999 年-2005 年先后在美国National Jewish M&R Center，Cold Spring Harbor Laboratory和Duke 大学从事博士后及研究助理工作。2005年2月回国，任中国科学院生物物理研究所“百人计划”研究员。于2017年7月正式加入中山大学医学院， 任教授。2023年，创立深圳市炎症性疾病系统医学重点实验室并任首任主任。

刘迎芳教授主要从事与感染性疾病、天然免疫相关的重大疾病的生物学及基础医学研究，在Nature、Cell、NSMB、Genes & Development、Molecular Cell、PNAS、Science Signaling、Cell Research、Nature Communications等期刊以第一作者或通讯作者发表过系列重要研究论文，特别是在流感病毒复制机制方面取得了具有重要国际影响的研究突破。其作为主要贡献人的研究成果：流感病毒聚合酶复制机制研究曾经被中央电视台CCTV新闻联播节目播报，并在国家“十二五重大科技成果展”中作为中国生物学科研两项重要成果之一获展。目前，国外根据刘迎芳教授等实验室发现的流感病毒PA亚基的功能和结构开发的强大的新型抗流感药物玛巴洛沙韦（中文名：速福达）已经上市，这对预防和治疗流感疾病具有重大的意义。最近，刘迎芳教授实验室发现了人体中一种新型炎症因子家族蛋白。由于此类炎症因子大都被开发或正在开发成临床应用产品，预期此项发现很有可能带来针对各类炎症疾病的新的临床检测和治疗试剂。基于此项原始科学发现的脓毒症诊疗试剂产业化项目获批国家重点研发计划颠覆性科技创新专项立项支持。

刘迎芳研究员是国家杰出青年基金获得者（2010年），享受政府特殊津贴专家
（2013年），国家百千万人才入选者（2009年），归侨贡献奖获得者（2012 年），“百人计划”终期考核优秀获评者，罗氏中国青年科学家奖获得者，多项863、973及国家自然科学基金等重大、重点项目课题或子课题承担人。作为第一完成人

于2012年获得北京市科技成果一等奖。目前是中山大学二级教授。2018年入选广东省医学领军人才，入选2019年度广东省珠江领军人才计划，其作为团队带头人的2019年度“珠江引进人才创新创业团队”项目也获得立项。 

主持的在研国家重点研究计划项目：炎症免疫性疾病新靶点新机制发现及原创药关键核心技术研究。 国家战略性科技创新合作重点专项（项目编号： 2022YFE0210000。时间：2024年01月01日-2026年12月31日）。

5 篇已发表的代表性论文：
1.    Zhikai Xiahou, Xiangli Wang, Juan Shen, Xiaoxiao Zhu, Feng Xu, Rong Hu, Deyin Guo, Henan Li, Yong Tian, Yingfang Liu*, and Huanhuan Liang* NMI and IFP35 serve as proinflammatory DAMPs during cellular infection and injury. Nat Commun. 2017; 8: 950. Published online 2017 Oct 16. doi: 10.1038/s41467-017-00930-9.
2.    Xizhong Jing, Yongjie Yao, Danning Wu, Hao Hong, Feng Xu, Na Xu, Yingfang Liu*, Huanhuan Liang*. Extracellular IFP Family Proteins Trigger Neuroinflammation and Exacerbate Multiple Sclerosis. Proc Natl Acad Sci U S A. 2021. Aug 10;118(32):e2102642118. doi: 10.1073/pnas.2102642118.
3.    Chang, S. *, Sun, D. *, Liang, H. *, Wang, J., Li, J., Guo, L., Wang, X., Guan, C., Boruah, B.M., Yuan, L., Feng, F., Yang, M., Wang, L., Wang, Y., Wojdyla, J., Li, L., Wang, J., Wang, M., Cheng, G., Wang, H-W*., Liu, Y*. Cryo-EM structure of influenza virus RNA polymerase complex at 4.3 Å resolution. Mol Cell. 2015, 5;57(5):925-35.
4.    Puwei Yuan, Mark Bartlam, Zhiyong Lou, Shoudeng Chen, Jie Zhou, Xiaojing He, Zongyang Lv, Ruowen Ge, Xuemei Li, Tao Deng, Ervin Fodor, Zihe Rao* & Yingfang Liu* (2009). Crystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active site. Nature, 458(7240):909-13.
5.    Xiaojing He, Jie Zhou, Mark Bartlam, Rongguang Zhang, Jianyuan Ma, Zhiyong Lou, Xuemei Li, Jingjing Li, Andrzej Joachimiak, Zonghao Zeng, Ruowen Ge, Zihe Rao*, Yingfang Liu*(2008). Crystal structure of the polymerase PA_C:PB1_N complex from an avian influenza H5N1 virus. Nature, 454(7208):1123-6.

简要说明：文章 3、4、5 发现流感病毒新靶点，带来新型抗流感药物玛巴洛沙韦
（速福达）的开发。文章 1、2 发现人体中新炎症因子，预计将为一些急慢性炎症性疾病带来全新的诊疗试剂。

已发表及在投稿中的论文整体情况

1.    Yongjie Yao, Zhenxing Chen, TianJiao Cui, Run Gong, Bishuang Gong, Lanjun Jing, Na Xu, Yixi Wu, Zhuangfeng Weng, Chun Tang, Zhihua Zheng, Yingfang Liu*, and Huanhuan Liang*. NMI Functions as a Type I Interferon-Inducible DAMP that Drives

Systemic Lupus Erythematosus Progression via Neutrophil Recruitment and NETosis. (under review)
2.    Yaqi Gao1, Jingjing Wang, Zhen Qin, Tianli Sun, Xiaoran Guo, Zhenxing Chen, Yunhua Xu, Yongjie Yao, Haoxue Yang, Jihua Zhang, Tingting Li, Na Xu, Zhuangfeng Weng, Tao Xu*, Yingfang Liu*, Huanhuan Liang*. NMI promotes the secretion of IL-17 and exacerbates psoriasis.(under revision)
3.    Minke Li , Yixi Wu, Huanhuan Li, Wenjun Song, Zhenxing Chen, Yuzhou Peng, Boyao Yang, Chang Xu, Jihua Zhang, Lei Xing, Zhuangfeng Weng*, Yingfang Liu*, Huanhuan Liang*. Mutagenesis studies suggest a
mechanism for influenza polymerase stalling during polyadenylation. Nucleic Acids Res. 2024 Dec 16:gkae1225. doi: 10.1093/nar/gkae1225. Online ahead of print.PMID: 39676676
4.    Huanhuan Li, Yixi Wu, Minke Li , Lu Guo, Yaqi Gao , Quan Wang, Jihua Zhang, Zhaohua Lai, Xing Zhang, Lixin Zhu, Ping Lan, Zihe Rao, Yingfang
Liu*, Huanhuan Liang*. An intermediate state allows influenza polymerase to switch smoothly between transcription and replication cycles. Nat Struct Mol Biol . 2023 Aug;30(8):1183-1192. doi: 10.1038/s41594-023-01043-2. Epub 2023 Jul 24.
5.    Yang Yu, Na Xu Qi Cheng, Fei Deng, Meiqin Liu, Airu Zhu, Yuan-Qin Min, Dan Zhu, Wenbo Huang, Xu Feng, Xizhong Jing, Ying Chen, Daoyuan Yue, Yawei Fan, Chang Shu, Qing Guan, Zifeng Yang, Jincun Zhao, Wenjun Song, Deyin Guo, Huanliang Liu, Jindong Zhao, Ping Lan*, Zhengli Shi*, Yingfang Liu*, Xiaoping Chen* and Huanhuan Liang*. IFP35 as a promising biomarker and therapeutic target for the2 syndromes induced by SARS-CoV-2 or influenza virus. Cell Reports. 2021 Dec 21;37(12):110126. doi: 10.1016/j.celrep.2021.110126. Epub 2021 Dec 3.
6.    Xizhong Jing, Yongjie Yao, Danning Wu, Hao Hong, Feng Xu, Na Xu, Yingfang Liu*, Huanhuan Liang*. Extracellular IFP Family Proteins Trigger Neuroinflammation and Exacerbate Multiple Sclerosis. Proc Natl Acad Sci U S A. 2021. Aug 10;118(32):e2102642118. doi: 10.1073/pnas.2102642118.
7.    Jun Li, Daqi Yu, Lan Liu, Huanhuan Liang*, Qi Ouyang*, Yingfang Liu*. Structural study of the N-terminal domain of human MCM8/9 complex. Structure, 2021 May 22;S0969-2126(21)00164-7. doi: 10.1016/j.str.2021.05.006.
8.    Zhuangfeng Weng, Xinxin Shen, Jiefu Zheng, Huanhuan Liang*, Yingfang Liu*. Structural Basis of DEPTOR to Recognize Phosphatidic Acid Using its Tandem DEP Domains. J Mol Biol. 2021 Jun 25;433(13):166989. doi:
10.1016/j.jmb.2021.166989. Epub 2021 Apr 16.
9.    Panpan Hou#, Penghui Jia#, Kongxiang Yang#, Zibo Li , Tian Tian , Yuxin Lin , Weijie Zeng , Fan Xing , Yu Chen , Chunmei Li , Yingfang Liu, Deyin Guo* An unconventional role of an ASB family protein in NF-κB activation and inflammatory response during microbial infection and colitis Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):e2015416118. doi: 10.1073/pnas.2015416118.
10.    Panpan Hou, Kongxiang Yang, Penghui Jia, Lan Liu, Yuxin Lin, Zibo Li, Jun Li, Shuliang Chen, Shuting Guo, Ji'An Pan, Junyu Wu, Hong Peng, Weijie Zeng, Chunmei Li, Yingfang Liu, Deyin Guo*. A novel selective autophagy receptor, CCDC50, delivers K63 polyubiquitination-activated RIG-I/MDA5 for degradation during viral infection. Cell Research, 2021 Jan;31(1):62-79. doi: 10.1038/s41422- 020-0362-1. Epub 2020 Jul 1.
11.    Huan Zeng, Jun Li, Huiqin Xu, Huanhuan Li, Yingfang Liu*. Crystal structure of the winged-helix domain of MCM8. Biochem Biophys Res Commun. 2020 Jun 11;526(4):993-998. doi: 10.1016/j.bbrc.2020.03.150. Epub 2020 Apr 12.
12.    Wen Li, Xiuzhen Bai1, Jun Li,Yichao Zhao, Jingyan Liu,Huayu Zhao, Lan Liu, Miao Ding, Qingsong Wang, Fang-Yuan Shi, Mei Hou, Jianguo Ji,Ge Gao, Rong Guo, Yujie Sun, Yingfang Liu*, Dongyi Xu*. The nucleoskeleton protein IFFO1 immobilizes broken DNA and suppresses chromosome translocation during tumorigenesis. Nature Cell biology, Sep 23, 2019
13.    Ma X, Liu K, Li J, Li H, Li J, Liu Y, Yang C#, Liang, H.# A non-canonical GTPase interaction enables ORP1L-Rab7-RILP complex formationand late endosome positioning. Journal of Biological Chemistry 2018 Jul 16. pii: jbc.RA118.001854. doi: 10.1074/jbc.RA118.001854.
14.    Li H, Yang K, Wang W, Niu Y, Li J, Dong Y, Liu Y, Wang CC, Wang L#, Liang, H.#. Crystal and solution structures of human protein disulfide isomerase-like protein of the testis (PDILT) provide insight into its chaperone activity. Journal of Biological Chemistry 2018, 293(4):1192-1202.
15.    Zhikai Xiahou, Xiangli Wang, Juan Shen, Xiaoxiao Zhu, Feng Xu, Rong Hu, Deyin Guo, Henan Li, Yong Tian, Yingfang Liu*, and Huanhuan Liang* NMI and IFP35 serve as proinflammatory DAMPs during cellular infection and injury. Nat Commun. 2017; 8: 950. Published online 2017 Oct 16. doi: 10.1038/s41467-017-00930-9
16.    Chengcheng Guan, Jun Li, Dapeng Sun, Yingfang Liu*, and Huanhuan Liang*. The structure and polymerase-recognition mechanism of the crucial adaptor protein AND- 1 in the human replisome. J Biol Chem. 2017 Jun 9;292(23):9627-9636. doi: 10.1074/jbc.M116.758524. Epub 2017 Apr 5.
17.    Huanhuan Liang* and Yingfang Liu*. Gasdermins pore cell membrane to pyroptosis. Sci China Life Sci. 2016 Oct;59(10):1090-1092. Epub 2016 Sep 7.(Research Highlight).
18.    Kuo Zhang, Yuan Gao, Jingjing Li, Rebecca Burgess, Junhong Han, Huanhuan Liang, Zhiguo Zhang*, and Yingfang Liu*. A DNA binding winged helix domain in CAF-1 functions with PCNA to stabilize CAF-1 at replication forks. Nucleic Acids Res. 2016 Jun 20; 44(11): 5083–5094.
19.    Chang, S. *, Sun, D. *, Liang, H. *, Wang, J., Li, J., Guo, L., Wang, X., Guan, C., Boruah, B.M., Yuan, L., Feng, F., Yang, M., Wang, L., Wang, Y., Wojdyla, J., Li, L., Wang, J., Wang, M., Cheng, G., Wang, H-W*., Liu, Y*. Cryo-EM structure of influenza virus RNA polymerase complex at 4.3 Å resolution. Mol Cell. 2015, 5;57(5):925-35.
20.    Feng Feng, Linmin Yuan, Yao Wang , Christopher Crowley, Zongyang Lv, Jingjing Li, Yingfang Liu, Genhong Cheng, Su Zeng, Huanhuan Liang*(2013). Crystal structure and nucleotide selectivity of human IFIT5/ISG58. Cell Res. Jun 18. doi: 10.1038/cr.2013.80. [Epub ahead of print]
21.    Peng Zhang, Anna Reichardt, Huanghuang Liang, Yaya Wang, David Cheng, Roghiyh Aliyari, Genhong Cheng*, Yingfang Liu* (2012). Single Amino Acid Substitutions Switch TRAF5 towards TRAF3-like Specificity. Science Signaling. Nov 13;5(250):ra81. doi: 10.1126/scisignal.2003152.
22.    Zhenlin Yang, Huanhuan Liang, Ying Li, Qian Zhou, Wen Ye, Joy Fleming, Hongbing Shu and Yingfang Liu*(2012). ISG Structure reveals a novel RNA Binding Structure
and its Molecular Mechanisms. Cell research July 24. doi: 10.1038/cr.2012.111. [Epub ahead of print]
23.    Yanyong Kang, Dongfeng Zhao, Huanhuan Liang, Bin Liu, Qinwen Liu, Xiaochen Wang* & Yingfang Liu*(2012). Structural Study of TTR-52 Reveals the Functional Mechanisms of a Bridging Molecule in Apoptotic Cell Engulfment. Genes & Development. Jun 15;26(12):1339-50.
24.    Lin Li, Shenghai Chang, Junfeng Xiang, Qian Li, Huanhuan Liang, Yalin Tang*, Yingfang Liu*(2012). Screen Anti-influenza Lead Compounds That Target the PAC Subunit of H5N1 Viral RNA Polymerase. PLoS One 7(8): e35234. doi:10.1371/journal.pone.0035234 (Aug 24, 2012).
25.    Shoudeng Chen, Yihui Xu, Kuo Zhang, Xinlu Wang, Jian Sun, Guangxia Gao* and Yingfang Liu*(2012). Crystal structure of the N-terminal domain of ZAP: insights into how a zinc-finger protein specifically targets complex RNA. Nature Structural and Molecular Biology. 19(4):430-5. Epub 2012 Mar 11.
26.    Shixuan Liu, Maxim Balasov, Hongfei Wang, Lijie Wu, Igor Chesnokov* and Yingfang Liu*(2011) . Structural analysis of human Orc6 protein reveals a homology with transcription factor TFIIB. Crystal structure of the N-terminal domain of ZAP: insights into how a zinc-finger protein specifically targets complex RNA. Proc Natl Acad Sci U S A. 108(18):7373-8. Epub 2011 Apr 18.
27.    Lin Li, Sheng-Hai Chang, Jun-Feng Xiang, Qian Li, Huan-Huan Liang, Jian Li, Hong- Juan Bao, Yalin Tang* and Yingfang Liu*(2011). Screening Anti-influenza Agents that Target Avian Influenza Polymerase Protein PA(C) from Plant Extracts Based on NMR Methods. Chemistry Letters. 40(8):801-803
28.    Yanyong Kang, Jing Xu, Yong Liu,  Jian Sun,  Dapeng Sun,  Yingsong Hu,  Yingfang Liu*(2011). Crystal structure of the cell corpse engulfment protein CED-2 in Caenorhabditis elegans. Biochem Biophys Res Commun. 410(2): 189-194 [Epub ahead of print: May 17.]
29.    Cong Zhao, Zhiyong Lou, Yu Guo, Ming Ma, Yutao Chen, Shuaiyi Liang, Liang Zhang,Shoudeng Chen, Xuemei Li, Yingfang Liu*, Mark Bartlam and Zihe Rao*(2009). Nucleoside Monophosphate Complex Structures of the Endonuclease Domain from the Influenza Polymerase PA Subunit Reveal the Substrate Binding Site inside the Catalytic Center. J. Virology ,83(18):9024-9030.
30.    Yingfang Liu, Zhiyong Lou, Mark Bartlam, Zihe Rao.(2009). Structure-function studies of the influenza virus RNA polymerase PA subunit. Sci China C Life Sci， 52(5):450-8.(Review)
31.    Puwei Yuan, Mark Bartlam, Zhiyong Lou, Shoudeng Chen, Jie Zhou, Xiaojing He, Zongyang Lv, Ruowen Ge, Xuemei Li, Tao Deng, Ervin Fodor, Zihe Rao* & Yingfang Liu* (2009). Crystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active site. Nature, 458(7240):909-13.
32.    Xiaojing He, Jie Zhou, Mark Bartlam, Rongguang Zhang, Jianyuan Ma, Zhiyong Lou, Xuemei Li, Jingjing Li, Andrzej Joachimiak, Zonghao Zeng, Ruowen Ge, Zihe Rao*, Yingfang Liu*(2008). Crystal structure of the polymerase PA_C:PB1_N complex from an avian influenza H5N1 virus. Nature, 454(7208):1123-6.
33.    Wei Tian, Cong Ma, Yingfang Liu*&Tao Xu* (2008). An efficient co-expression and purification system for the complex of Stx4 and C-terminal domain of Synip. Biochemical and Biophysical Research Communications, 371(Issue 3, 4): 366-370.

34.    Xiaoyu Yang, Jie Zhou, Lei Sun, Zhiyi Wei, Jianying Gao, Weimin Gong, Rui-Ming Xu, Zihe Rao, and Yingfang Liu*(2007).Structural Basis for the Function of DCN-1 in Protein Neddylation. J. Biol. Chem. 282: 24490 – 24494.