邝栋明
教授、博士导师
研究方向:
邝栋明,中山大学二级教授,生命科学学院副院长,全国百优博士,国家杰出/优秀青年基金获得者,获聘教育部青年长江学者和广东省珠江学者特聘教授,入选中组部“万人计划”青年拔尖人才。研究工作专注于肿瘤免疫微环境、免疫治疗和抗肿瘤临床药理学,探讨以免疫细胞作为治疗靶标的可行性;主持国家基金委重大研究计划、专项项目、重点项目等资助;作为主要完成人获教育部高等学校科学研究优秀成果奖一等奖、广东省自然科学技术奖一等奖和国家自然科学奖二等奖。作为通讯作者在Cell、Immunity、Nat Med、Cancer Cell、Cancer Discov、Gastroenterology、Cell Res、J Clin Invest等发表系列论文。
5项代表性成果(*通讯作者)
[1] Wu CY, Huang CX, Lao XM, Zhou ZW, Jian JH, Li ZX, Wu YY, Liu ZY, Chen L, Liu L, Zheng L, Wei Y*, Kuang DM*. 2025. Glucose restriction shapes pre-metastatic innate immune landscapes in the lung through exosomal TRAIL. Cell. doi: 10.1016/j.cell.2025.06.027.
[2] Liu ZY, Wu CY, Wu RQ, Wang JC, Huang CX, Wang XY, Zhang Y, Zheng L, Chen Y*, Lao XM*, Chen DP*, Kuang DM*. 2025. Efflux of N1-acetylspermidine from hepatoma fosters macrophage-mediated immune suppression to dampen immunotherapeutic efficacy. Immunity. 58:1572-1585.
[3] Huang CX, Lao XM, Wang XY, Ren YZ, Lu YT, Shi W, Wang YZ, Wu CY, Xu L, Chen MS, Gao Q, Liu L, Wei Y*, Kuang DM*. 2024. Pericancerous cross-presentation to cytotoxic T lymphocytes impairs immunotherapeutic efficacy in hepatocellular carcinoma. Cancer Cell. 42:2082-2097.
[4] Wu RQ, Lao XM, Chen DP, Qin H, Mu M, Cao WJ, Deng J, Wan CC, Zhan WY, Wang JC, Xu L, Chen MS, Gao Q, Zheng L, Wei Y*, Kuang DM*. 2023. Immune checkpoint therapy-elicited sialylation of IgG antibodies impairs antitumorigenic type I interferon responses in hepatocellular carcinoma. Immunity. 56:180-192.
[5] Lv J, Wei Y, Yin JH, Chen YP, Zhou GQ, Wei C, Liang XY, Zhang Y, Zhang CJ, He SW, He QM, Huang ZL, Guan JL, Shen JY, Li XM, Li JY, Li WF, Tang LL, Mao YP, Guo R, Sun R, Zheng YH, Zhou WW, Xiong KX, Wang SQ, Jin X, Liu N*, Li GB*, Kuang DM*, Sun Y*, Ma J*. 2023. The tumor immune microenvironment of nasopharyngeal carcinoma after gemcitabine plus cisplatin treatment. Nat Med. 29:1424-1436.

